解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Oral treatment with reduced glutathione for 10 weeks has no effect on the development of tumours from aflatoxin B1-induced gamma-glutamyl transpeptidase-positive pre-neoplastic focal lesions. ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90086-1
更新日期:1983-11-01 00:00:00
abstract::Butylated hydroxyanisole (BHA) was given to pregnant SPF pigs (Danish Landrace) in doses of 0, 50, 200 and 400 mg/kg body wt per day for 110 days. BHA was mixed in the diet (pelleted). Hyperkeratotic and parakeratotic proliferative changes of the stratified epithelium of the stomach were found at various degree in bot...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90090-3
更新日期:1983-11-01 00:00:00
abstract::A Mr 60,000 protein, detected by its ability to induce the release of RNA from isolated nuclei, is present in the plasma of tumor-bearing and carcinogen-treated rats, together with low amounts of 2 messenger RNA transport proteins identified earlier in normal cells. The Mr 60,000 protein has been identified in tumor c...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90025-3
更新日期:1983-10-01 00:00:00
abstract::N'-Nitrosonornicotine (NNN) or N'-nitrosonornicotine-1-N-oxide (NNN-1-N-oxide), one of its metabolites, was added to the drinking water (0.012% for 36 weeks) of groups of male and female F344 rats or to the drinking water (0.016% for 31 weeks) of groups of male and female Syrian golden hamsters. All rats treated with ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90032-0
更新日期:1983-10-01 00:00:00
abstract::The effects of di(2-ethylhexyl)phthalate (DEHP), a widely used plasticizer and environmental contaminant, on the emergence of gamma-glutamyltrans-peptidase positive (GGT+) preneoplastic foci in the liver was investigated. Sprague--Dawley male rats initiated with diethylnitrosamine (DEN) following partial hepatectomy w...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90049-6
更新日期:1983-09-01 00:00:00
abstract::Xanthine oxidase reduction of adriamycin (Am) and daunorubicin (Dm) to their respective 7-deoxy aglycones is inhibited by allopurinol. Administered to DBA/2 mice with L1210 leukemia, allopurinol (60 mg/kg per day X 3) enhances the antitumor activity of adriamycin. ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90189-1
更新日期:1983-08-01 00:00:00
abstract::Membrane glycoprotein synthesis was studied in non-tumorigenic and tumor cells treated with the lymphokine hormone, lymphotoxin, to define the biochemical mechanisms by which lymphotoxin prevents carcinogenesis and inhibits growth of tumor cells. Syrian hamster lymphotoxin increased the synthesis of high molecular wei...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90096-4
更新日期:1983-07-01 00:00:00
abstract::Binding of 1-nitro[14C]pyrene (1-NP) or its metabolites to cellular DNA and protein in cultures of rabbit alveolar macrophages and lung and tracheal tissues was examined. DNA binding was highest in tracheal tissue (136.9 +/- 18.3 pmol 1-NP/mg DNA). DNA binding in macrophages and lung tissue was one-fifth of the level ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90091-5
更新日期:1983-07-01 00:00:00
abstract::Soil samples were collected from the ground under the plants of Euphorbiaceae and Thymelaeaceae known to possess Epstein-Barr virus-activating diterpene esters. In a test system, the ether extracts of such soil samples at a concentration of 20 micrograms/ml induced Epstein-Barr virus early antigen in approximately 5-2...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90144-1
更新日期:1983-06-01 00:00:00
abstract::The in vitro sensitivities to differentiating agents of a murine neuroblastoma cell line (N18) and a selected variant cell line (N18-LM5) were examined. In addition, the sensitivities to differentiating agents of cells from spontaneous metastases produced by N18 cells were examined. When N18 cells (1 X 10(5) cells/mou...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90133-7
更新日期:1983-05-01 00:00:00
abstract::The renal handling of cisplatin was investigated in Sprague-Dawley rats in the presence and absence of probenecid and N'-methylnicotinamide. The renal clearance of free cisplatin was not significantly different from the glomerular filtration rate. N'-Methylnicotinamide, an organic cation, did not affect cisplatin clea...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90143-x
更新日期:1983-05-01 00:00:00
abstract::The susceptibility of analbuminemic rats, a mutant strain of Sprague-Dawley rats, to bladder carcinogens was examined by testing the agglutinability of isolated bladder epithelial cells by Concanavalin A (Con A). One-week treatment with 0.001% N-butyl-N-(4-hydroxybutyl)nitrosamine (BHBN) in the drinking water or 0.01%...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90128-3
更新日期:1983-05-01 00:00:00
abstract::Incubation of mouse epidermal cells (HEL-37) with phospholipase C (Clostridium perfringens) caused about a 50% decrease in the specific binding of [20-3H]phorbol-12,13-dibutyrate. Phospholipase C caused a decrease in the apparent number of binding sites from 2.86 X 10(5) to 1.21 X 10(5) per cell with little effect on ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90141-6
更新日期:1983-05-01 00:00:00
abstract::The mutagenic activities of N-nitrosobis(2-hydroxypropyl)amine (BHP) and its related compounds were studied in Salmonella typhimurium TA100 and TA98 strains by Ames's liquid incubation assay in the presence or absence of lung and liver S9 of rats treated with polychlorinated biphenyl (PCB). BHP and its related compoun...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90235-5
更新日期:1983-04-01 00:00:00
abstract::The effect of dose was evaluated for the bladder carcinogenicity of N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide (FANFT). The chemical was fed to male weanling F344 rats for 30 weeks followed by 74 weeks of control diet. The incidences of bladder carcinoma were 100, 100, 87, 0, 0 and 0% for doses of 0.2, 0.1, 0.05, 0...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90234-3
更新日期:1983-04-01 00:00:00
abstract::The cell transforming ability of asbestos dust was investigated using C3H10T 1/2 murine fibroblasts. In a series of experiments both crocidolite and amosite caused no increase in the number of transformed foci over that seen in cultures from untreated cells. The dusts, were, however, capable of augmenting the oncogeni...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90071-x
更新日期:1983-03-01 00:00:00
abstract::The effects of different sources of dietary protein, fat and carbohydrate on tumor development and on tests relating to cell-mediated immunity were investigated in male BALB/c mice after subcutaneous injection of 8 X 10(4) 1,2-dimethylhydrazine (DMH)-induced colon tumor (no. 51) cells. Results indicated that mice fed ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90117-9
更新日期:1983-02-01 00:00:00
abstract::Benzo[a]pyrene (B[a]P) metabolism and macromolecular binding have been studied in explants from 4 tissues, bladder, skin, bronchus and esophagus from 8 donors sampled within 4 h after death. Explants were incubated with [3H]benzo[a]pyrene for 24 h, then the metabolites extracted and analyzed by high-pressure liquid ch...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90112-x
更新日期:1983-02-01 00:00:00
abstract::The effect of Pseudomonas aeruginosa colonizing in the gut on the development of gastrointestinal tumors was studied in rats treated orally with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The animals were inoculated with or accidentally colonized by P. aeruginosa after MNNG treatment. In 3 serial experiments, P. aer...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90174-x
更新日期:1983-01-01 00:00:00
abstract::Tobacco-specific N-nitrosamines (TSNA) are the most abundant carcinogens identified in tobacco and its smoke. Reducing their levels in tobacco products and especially in cigarette smoke is, therefore, a primary goal towards minimizing the carcinogenic burden of the tobacco consumer. This study delineates the mechanism...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90173-8
更新日期:1983-01-01 00:00:00
abstract::Continuous ethinyl estradiol treatment following ovariectomy at day 38 of BALB/cfC3H mice treated neonatally with estradiol resulted in a more organized vaginal epithelium than that seen in the absence of postnatal estrogen, 30 days after treatment was initiated. Although the epithelium became increasingly disorganize...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(82)90023-4
更新日期:1982-11-01 00:00:00
abstract::Herpes simplex virus was grown in different lines of human tumor and normal cells. The progeny virus was assayed for resistance to iododeoxycytidine, an indicator of a forward mutation in the virus genome. Virus grown in cells from 4 of 5 tumor lines demonstrated greater fractions mutated to iododeoxycytidine resistan...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(82)90026-x
更新日期:1982-11-01 00:00:00
abstract::The pineal has been recently implicated in mammary tumorigenesis. Effect of physiological pinealectomy brought about by subjecting female Holtzman rats to permanent lighting (24 h/day) from birth was studied on the incidence of 9,10-dimethyl-1,2-benzanthracene (DMBA) induced mammary tumors. The incidence of adenocarci...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(82)90012-x
更新日期:1982-09-01 00:00:00
abstract::Receptors for all classes of steroid hormones were identified in cytosols of adenocarcinoma of the lung. In contrast, the incidence of receptor in squamous cell carcinoma was limited and small cell carcinomas appeared devoid of receptor. Receptor binding was of high affinity, saturable and localized to the 8, 6-7 and ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(82)90014-3
更新日期:1982-09-01 00:00:00
abstract::Cooking beef patties results in the formation of mutagens detectable by Salmonella typhimurium TA98 with metabolic activation. Decreased mutagenic activity results when frying beef with added soy protein concentrates (SPC). The reduction in mutagenicity takes place during the cooking process. Whereas fried beef hambur...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(82)90059-3
更新日期:1982-07-01 00:00:00
abstract::The effects of the ornithine decarboxylase suicide substrate, difluoromethylornithine (DFMO), and of cyclophosphamide, individually and in combination, on the growth of the R3327MAT-Lu prostate derived tumor were determined. DFMO decreased the growth rate and resulted in a 75% reduction in DNA content compared to the ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(82)90093-3
更新日期:1982-05-01 00:00:00
abstract::The binding of [14C] azaserine or its metabolites to DNA and protein in the organs of rats and hamsters was determined at various time after treatment with [14C] azaserine. The specific activity of 14C labelling of DNA and protein was determined. Rat liver DNA and protein were most extensively labelled at 90 min post-...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(82)90092-1
更新日期:1982-05-01 00:00:00
abstract::The growth of primary subcutaneous fibrosarcomas and their pulmonary metastases was studied in normal and athymic Swiss mice. The metastases tended to develop more rapidly than did the primary tumors. However, when growth rates of tumors of small volumes (up to 1 cm3) were compared, the tumor and metastases exhibited ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(82)90129-x
更新日期:1982-03-01 00:00:00
abstract::The effects of glucocorticoids and cholesterol on morphological transformation have been studied using hamster embryo cells. The cells were exposed sequentially to benzo[a]pyrene (BP) (3 days) and the tumor promotor 12-O-tetradecanoylphorbol-13-acetate (TPA) (4 days) before scoring for morphologically transformed colo...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(82)90039-8
更新日期:1982-02-01 00:00:00
abstract::Methylnitrosourea (MNU)-induced carcinomas in organ-cultured human pancreas when injected into nude mice produced subcutaneous carcinomas none of which recognizable as being of acinar cell origin. Both monoclonal antibody to acinar cell surface marker produced by hybridoma, and in vitro tumor cell differentiation were...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(82)90040-4
更新日期:1982-02-01 00:00:00
abstract::The formation of nitroso compounds and mutagens from 5 nitrogen-containing drugs (cinnarizine, ethambutol, piromidic acid, pyridinol carbamate and tiaramide) by drug/nitrite interaction was examined. On the reaction of 50 micrometers drug and 500 micrometers nitrite at pH 3.0--3.4 and 37 degrees C for 4 h, the conside...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(82)90075-1
更新日期:1982-01-01 00:00:00
abstract::Irradiation with 90Sr-90Y beta rays induced ornithine decarboxylase (ODC) activity in mouse skin. Maximum activity appeared after about 17 days, at the time of appearance of skin injuries. These findings suggest the presence of tumor-promoting activity of beta rays. ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(82)90070-2
更新日期:1982-01-01 00:00:00
abstract::Poly(ADP-ribose) synthetase activity in human cervical cancer cell nuclei was found to be approximately twice that of normal cervical cell nuclei. Using antipoly(ADP-ribose) antibody, frozen section of normal tissue were stained by indirect-immunofluorescence and it was demonstrated that the fluorescence of nuclei in ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(81)90148-8
更新日期:1981-12-01 00:00:00
abstract::Diet-induced changes in serum cholesterol levels and their relationship to mammary carcinogenesis initiated by 7,12-dimethylbenz[a]anthracene (DMBA) were studied in female Sprague-Dawley rats. DMBA was given to rats subjected to 3 dietary treatments: (1) a semipurified, cholesterol-free diet (SP); (2) the same diet wi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(81)90154-3
更新日期:1981-12-01 00:00:00
abstract::The synthetic compound 1,2-dimethylhydrazine is employed in carcinogenesis studies because of its reliable and specific ability to produce colon tumors in rodents. Male Fischer rats were treated at 7 weeks of age with a single oral dose of 1,2-dimethylhydrazine (35 mg/kg) and examined at autopsy 1.5 years later when t...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(81)90008-2
更新日期:1981-10-01 00:00:00
abstract::The effect of selenium was examined on the growth potential of normal, preneoplastic and neoplastic mammary cells grown in primary monolayer cell cultures and on 3 established mammary cell lines. Selenium, present as Na2SeO3 in serum-free DMEM, inhibited all mammary cell cultures at 1 x 10(-5) M. Selenium, at 5 x 10(-...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(81)90062-8
更新日期:1981-09-01 00:00:00
abstract::The comparative effects of the subchronic administration to rats of ethionine-supplemented and of chemically defined methyl-deficient diets on the hepatic levels of S-adenosylmethionine (SAM) and of ornithine decarboxylase (ODC), an enzyme marker of cell proliferation, were studied. Both treatments led to decreased he...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(81)90018-5
更新日期:1981-08-01 00:00:00
abstract::Vinblastine inhibited the growth of cultured KB cells 3 days after drug treatment by 55% and 67% at 2.7 ng/ml and 3.5 ng/ml of the medium, respectively. Lysolecithin and phosphatidylinositol showed only a marginal inhibitory effect on the growth of KB cells at respective concentrations of 35-125 microgram/ml and 50-15...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(81)90139-7
更新日期:1981-07-01 00:00:00
abstract::Carcinogenicity of quercetin and rutin were examined in inbred ACI strain rats. Rats were given a diet containing 1% or 5% quercetin or 5% rutin for 540 days, or 10% quercetin and 10% rutin for 850 days. Rats in control groups were fed a normal basal diet. Most tumors found in experimental groups were also found in th...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(81)90081-1
更新日期:1981-06-01 00:00:00
abstract::Retinoic acid and retinol induced functional and morphological differentiation of human promyelocytic leukemia cells (HL-60) into mature granulocytes, but did not induce functional or morphological differentiation of mouse myeloid leukemia cells (M1). Cellular retinoic acid-binding protein, but not retinol-binding pr...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(81)90079-3
更新日期:1981-06-01 00:00:00